What is Ocular Surface Disease?
Ocular surface disease is caused by damage to, or dysfunction and/or deficiency of any of the anatomical parts of the cornea and conjunctiva. Patients with severe ocular surface disease caused by the diseases listed below, have no alternative medical or surgical therapies that can restore their vision and can benefit from a stem cell transplant and/or ocular surface reconstruction.
- Chemical and Thermal Burn Injuries
- Congenital disorders that affect the ocular surface (Ex. Aniridia and Keratitis-Ichthyosis-Deafness (KID) Syndrome)
- Steven-Johnson’s Syndrome
- Contact Lens Related
- Iatrogenic: damage from prior eye medication or surgery
- Graft versus Host Disease
- Limbal Stem Cell Deficiency: lack of healthy limbal stem cells leading to corneal scarring and damage
Patients that have these diseases can be legally blind and often have chronic ocular pain. These eyes develop corneal scarring because with dysfunctional or deficient stem cells at the limbus; the surface cornea cells (epithelium) are unable to propagate in an orderly fashion.
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